SYMPTOM PERCEPTION IN CRITICAL ADOLESCENT ASTHMA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该方案试图了解哮喘死亡的风险因素之一，即为什么一些患有哮喘的青少年无法感知其呼吸道症状的变化。有证据表明，这种对呼吸状态变化的感知能力下降是哮喘死亡或严重并发症的风险因素，但尚不清楚无法感知症状是由于潜在的神经生理缺陷，还是由于心理因素。了解问题的原因是为这些处于危险中的青少年制定适当的治疗和/或预防战略的关键。在这项三个地点的研究中，我们预计将研究96名患有危及生命的哮喘发作(LTA)的青少年，并将他们与性别、年龄和种族匹配的两个对照组进行比较：有哮喘但没有LTA的组，以及没有内科疾病的组。我们将使用三种不同的范例来确定每个青少年检测呼吸道症状变化的能力。然后，我们将检查基本的神经生理感觉系统，以及心理因素，看看哪些与症状感知有关。仅限数据分析方面的研究05/

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol seeks to understand one of the risk factors for asthma death, i.e., why some adolescents with asthma are unable to perceive changes in their respiratory symptoms. There is evidence that this decreased perception of changes in respiratory status is a risk factor for death or serious complications from asthma, but it is unknown whether the inability to perceive symptoms is due to an underlying neurophysiologic deficit, or whether it is due to psychological factors. Understanding the etiology of the problem is key to developing appropriate treatment and/or prevention strategies for those adolescents at risk. In this three site study, we anticipate studying 96 adolescents who have had a life threatening asthma episode (LTA), and we will compare them to two control groups that are matched on gender, age and ethnicity: a group with asthma, but no LTA, and group with no medical illnesses. We will determine each adolescents ability to detect changes in respiratory symptoms using three different paradigms. We will then examine basic neurophysiological sensory systems, as well as psychological factors, to see which are related to symptoms perception. Study in Data Analysis Only 05/