EPIDEMIOLOGY OF DIABETES INTERVENTIONS AND COMPLICATIONS (EDIC)

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。2006年1月，DCCT/EDIC进入队列随访的10年延长期。核心协议与EDIC前12年遵循的基本协议相同。糖尿病控制和并发症试验（DCCT）和糖尿病干预和并发症流行病学（EDIC）随访研究已经确定了强化糖尿病治疗对视网膜病变、肾病、神经病变和心血管疾病（CVD）的短期和长期影响。此外，他们还确定了高血糖症和其他危险因素对并发症发展和进展的作用。DCCT/EDIC的先前结果在开发已在全球采用的1型糖尿病的现代疗法方面具有开创性意义。DCCT/EDIC队列已采用一致的、经验证的方法随访平均16（13-20）年，保留率为94%，代表了历史上最仔细研究的1型糖尿病患者组。目前的方案描述了DCCT/EDIC队列的进一步随访，目标是：确定原始干预对晚期并发症的长期影响;探索印记的寿命，（“代谢记忆”）现象;描绘糖尿病并发症的现代临床过程，包括并发症之间的相互作用和并发症的共同发生;检查强化治疗与常规治疗对心血管事件的长期（较长期）影响;探索微血管、神经系统和心血管并发症发生和进展的病理生理机制;并确定强化治疗的长期生活质量和经济影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In January 2006, the DCCT/EDIC enters the 10-year extension of the follow-up of the cohort. The Core protocol is the same as the basic protocol followed for the first 12 years of EDIC. The Diabetes Control and Complications Trial (DCCT) and the Epidemiology of Diabetes Interventions and Complications (EDIC) follow-up study have established the short-term and longer-term impact of intensive diabetes therapy on retinopathy, nephropathy, neuropathy, and cardiovascular disease (CVD). In addition, they have defined the roles of hyperglycemia and other risk factors on the development and progression of complications. The previous results of DCCT/EDIC have been seminal in developing the modern-day therapy of Type 1 diabetes that has been adopted worldwide. The DCCT/EDIC cohort has been followed with consistent, validated methods for a mean of 16 (13-20) years with 94% retention and represents the most carefully studied group of Type 1 diabetic patients in history. The current protocol describes further follow-up of the DCCT/EDIC cohort with the goals of: determining the very long-term effects of the original interventions on advanced complications; exploring the longevity of the imprinting ("metabolic memory") phenomenon; delineating the modern-day clinical course of diabetic complications including the interactions among complications and co-occurrence of complications; examining the long (er)-term effects of intensive vs. conventional therapy on cardiovascular events; exploring the pathophysiologic mechanisms that underlie the development and progression of microvascular, neurologic, and cardiovascular complications; and defining the long-term quality of life and economic impacts of intensive therapy.