ANAL DYSPLASIA AND ANAL HPV IN HIV-POSITIVE AND HIV-NEGATIVE MEN

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是：确定在高活性抗逆转录病毒治疗（HAART）时代，与HIV阴性对照相比，HIV阳性男性中肛门鳞状上皮内病变（ASIl）的患病率；研究免疫参数、性行为报告、种族、HIV感染和HPV感染与ASIL流行的关系；并比较有肛交史的HIV阳性男性、无肛交史的HIV阳性男性和HIV阴性对照者肛门HPV感染的患病率和持久性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aims of this study are: to define the prevalence of anal squamous intraepithelial lesions (ASIl) among HIV+ men in the era of highly active anti-retroviral therapy (HAART) as compared to HIV-negative controls; to examine the association of immunologic parameters, reported sexual behavior, race, HIV infection and HPV infection on prevalent ASIL; and to compare the prevalence and persistence of anal HPV infection between HIV+ men with a history of receptive anal intercourse, HIV+ men without this history, and HIV-negative controls.