VALIDATION OF A METHOD TO QUANTITATE BILIARY EXCRETION IN HUMANS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是测试一种测量通过胆囊排出体外的药物量的方法。药物通过胆囊排出的程度很难测量，而且通常是未知的，但它可能会极大地影响药物在体内停留的时间和给药的频率。我们希望使用这个工具来测量通过胆囊的药物清除。最终，我们计划将这项研究的结果与细胞培养技术的结果联系起来，这反过来可能用于预测人类胆囊药物去除。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to test a method for measuring the amount of a drug removed from the body through the gallbladder. The extent of drug removal through the gallbladder is difficult to measure and often is unknown, but it may greatly affect how long a drug stays in the body and how often a drug should be administered. We hope to use this tool to enable measurement of drug removal through the gallbladder. Ultimately, we plan to correlate the results of this study with results from a cell culture technique, which in turn may be used to predict gallbladder drug removal in humans.