ENDOCRINE DYSFUNCTION AND GROWTH HORMONE DEFICIENCY IN CHILDREN WITH ONH

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是研究视神经发育不全（ONH）患儿的内分泌病变。这项拟议的研究将是第一个专门评估大量ONH儿童内分泌和生长结果，以及生长激素治疗对身体发育的影响的研究。受试者将随机分为生长激素治疗组和仅观察组（无安慰剂对照），随访两年观察生长结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to study endocrinopathies in children diagnosed with optic nerve hypoplasia (ONH). The proposed study will be the first to specifically evaluate a large number of ONH children for endocrinological and growth outcomes, and the impact of growth hormone treatment on physical development. Subjects will be randomized to treatment with growth hormone vs observation only (no placebo control) and followed for two years for growth outcomes.