Interdisciplinary Training in Genetics and Complex Disease(RMI)

我们的培训拨款建议“遗传学和复杂疾病的跨学科培训”直接满足了以综合的方法发展博士后和博士后培训的需要，以应对当今公共卫生科学的挑战。我们的目标是培养一支年轻的科学家队伍，他们可以参与分子生物学、流行病学和生物统计学的交叉学科，成为综合和团队方法的领导者，了解公共卫生领域的遗传学和复杂疾病。在后基因组时代，我们开始理解和汇编人类群体内遗传变异的广度。这些信息的精细化使用需要开发先进的生物统计分析方法。此外，现代流行病学研究还对健康风险暴露进行了改进，将饮食、生活方式、新陈代谢变化、社会经济状况等因素包括在内。 以及环境暴露(如污染物、毒物)。后一种扩展的观点提供了关于环境对复杂疾病的影响的更有意义和更精确的研究。最后，为了在疾病预防方面取得重大进展，这是公共卫生的一个标志，迫切需要将遗传进展转化为侧重于预防常见且代价高昂的慢性病的计划和政策。 只有了解基因图谱的重要性，我们才能确定谁将真正从公共干预中受益。如果我们要真正了解与多种环境因素相互作用的常见遗传修饰物的性质，就需要一个新的科学和新的科学工具箱。我们寻求建立一条跨学科教育的新轨道，跨越分子生物学、流行病学和生物统计学的边界，以细胞生理学和新陈代谢为核心基础，开发专注于复杂疾病中上下文相关的基因-环境相互作用的关键概念。我们对受训者的特别关注是在最广泛的意义上的基因-环境相互作用，以及一组广泛的复杂疾病，而不是单个的综合症，认识到今天的科学在很大程度上是以几个交叉学科的“核心”领域为基础的。我们将开发综合课程，主办研讨会，建立新的研讨会系列，并培养互动的“核心”，使我们的受训人员能够应对未来的挑战 定义疾病模式的分子特征。

Our training grant proposal "Interdisciplinary Training in Genetics and Complex Diseases" directly meets the need to develop pre- and post-doctoral training in an integrative approach to meet the challenges of today's public health science. Our goal is to develop a cadre of young scientists who can participate at the intersection of molecular biology, epidemiology, and biostatistics to become leaders in integrative and team approaches to understanding genetics and complex diseases in the public health arena. In the post-genomic era we are beginning to comprehend and compile the breadth of genetic variation within the human population. Refined use of this information requires the development of advanced methods of biostatistical analyses. In addition, modern epidemiological studies have evolved an enhanced view of health risk exposures to include factors such as diet, lifestyle, metabolic alterations, socioeconornic status along with environmental exposures (e.g., pollutants, toxicants). The latter expanded view provides more meaningful and precise studies of environmental contributions to complex disease. Finally, to make significant progress in disease prevention, a hallmark of public health, there is a pressing need to translate genetic advances into programs and policies focused on preventing common and costly chronic diseases. Only by understanding the importance of genetic profile can we identify who will truly benefit from public interventions. A new science and new scientific toolbox will be needed if we are to truly understand the nature of common genetic modifiers that interact with multiple environmental factors. We seek to establish a new track for interdisciplinary education that intersects the boundaries of molecular biology, epidemiology and biostatistics with a core foundation in cell physiology and metabolism that will develop key concepts focused on context-dependent gene-environment interactions in complex diseases. Our specific focus for trainees is on gene-environment interactions in the broadest possible sense, and on a generalized set of complex diseases rather than on an individual syndrome, with the recognition that science today is becoming substantially predicated in several "core" areas that intersect across disciplines. We will develop integrated coursework, sponsor workshops, establish a new seminar series, and foster interactive "cores" to enable our trainees to undertake the challenges that lie ahead to define the molecular signatures of disease patterns.