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SPHINGOLIPID METABOLISM IN THE RETINA

SPHINGOLIPID METABOLISM IN THE RETINA
视网膜中的鞘脂代谢
批准号:
7359083
负责人:
ALFRED Harrison MERRILL
金额:
$0.62万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-07-01 至 2007-06-30

项目摘要

项目成果

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中文摘要
翻译
这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金,因此可能会出现在其他CRISE条目中。列出的机构是针对中心的,而不一定是针对调查员的机构。用ESI-MS/MS法测定链脲佐菌素(STZ)糖尿病动物对照视网膜和视网膜神经酰胺代谢产物的含量。糖神经酰胺发生了重大变化,这些发现以及后续实验与糖鞘脂脂代谢功能障碍可能导致糖尿病代谢应激的假设一致。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ESI-MS/MS was used to measure ceramide content and ceramide metabolites in control retinas and retinas from animals with streptozotocin (stz)-diabetes. Major changes were seen in glucosylceramide, and these findings as well as follow-up experiments were consistent with the hypothesis that dysfunctional glyco-sphingolipid metabolism may contribute to metabolic stress in diabetes
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会议论文
INVESTIGATION OF 1-DEOXYDIHYDROCERAMIDE BIOSYNTHESIS BY MAMMALIAN CELLS
  • 批准号:
    8365570
  • 项目类别:
  • 资助金额:
    $1.54万
  • 财政年份:
    2011
  • 负责人:
    ALFRED Harrison MERRILL
  • 依托单位:
1-DEOXY-SPHINGOID BASE AND 1-DEOXYDIHYDROCER BIOSYNTHESIS IN MAMALS
  • 批准号:
    8170944
  • 项目类别:
  • 资助金额:
    $1.75万
  • 财政年份:
    2010
  • 负责人:
    ALFRED Harrison MERRILL
  • 依托单位:
Chemoprevention via modulation of autophagy by sphingolipids
  • 批准号:
    7860733
  • 项目类别:
  • 资助金额:
    $7.17万
  • 财政年份:
    2009
  • 负责人:
    ALFRED Harrison MERRILL
  • 依托单位:
Chemoprevention via modulation of autophagy by sphingolipids
  • 批准号:
    7590890
  • 项目类别:
  • 资助金额:
    $7.17万
  • 财政年份:
    2009
  • 负责人:
    ALFRED Harrison MERRILL
  • 依托单位:
国内基金
海外基金
一碳代谢(One carbon metabolism)介导上调的 PD1/PDL1 驱动 肿瘤免疫逃逸
  • 批准号:
    2024JJ9491
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2024
  • 负责人:
    彭罗根
  • 依托单位: