STRUCTURAL STUDIES OF PROTEINS FROM HYPERTHERMOHILIC VIRUSES

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。NE-CAT光束线的工作重点是确定STIV病毒蛋白B129的结构。这种蛋白质的功能不能通过使用BLAST搜索的序列相似性来确定，也不能通过CD搜索或线索来确定。然而，我们预计蛋白质的结构将允许我们识别结构同源物，从而形成关于其功能的可测试假说。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Work at the NE-CAT beamline was focused on determining the structure of the STIV viral protein B129. The function of this protein can not be determined by sequence similarity using BLAST searches, or by CD searches or threading. We anticipate, however, that the structure of the protein will allow us to identify structural homologs, and thus to formulate a testable hypothesis regarding its function.