INFLAMMATORY PROFILES OF CHILDREN AT HIGH RISK FOR ATHEROSCLEROSIS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。总体目标是通过描述父母或祖父母患有国家胆固醇教育计划（NCEP）(1)和美国儿科学会（AAP）(2)定义的过早动脉粥样硬化性疾病（病例）的儿童的炎症因子和已知心血管危险因素，以及没有此类家族史的对照组，更好地了解儿童时期炎症标志物水平升高与已证实的心血管危险因素之间的关系。病例和对照组将进一步分为有高脂血症组和无高脂血症组，以澄清高脂血症与早期动脉粥样硬化家族史之间的相互作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Overall goal is to better understand the relationship between elevated levels of inflammatory markers in childhood and proven cardiovascular risk factors, by describing inflammatory makers and known cardiovascular risk factors in children with parents or grandparents who have premature atherosclerotic disease (cases) as defined by the National Cholesterol Education Program (NCEP)(1) and the American Academy of Pediatrics (AAP), (2) and controls without such a family history. Cases and controls will be further divided into groups with and without hyperlipidemia to allow clarification of interaction between hyperlipidemia and family history of early atherosclerosis.