EARLY TREATMENT OF ALS WITH NUTRITION AND NIPPV

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这是一项多中心试点研究，旨在为确定的III期试验开发方法。本试点研究的具体目的是：1)制定和验证提高NIPPV耐受性的策略，确定影响接受这种治疗方式的因素，并评估早期呼吸功能障碍的措施；2)开发和验证确定ALS患者能量平衡的方法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a multicenter Pilot Study to develop methods for a definitive Phase III trial. The specific aims of this Pilot Study are 1) To develop and validate strategies to improve tolerability of NIPPV, to identify factors that influence acceptance of this treatment modality, and to evaluate measures of early respiratory dysfunction; and 2) To develop and validate methods to determine energy balance in ALS.