COCOA, POLYPHENOLS AND THE KIDNEY IN HEALTHY HUMANS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。揭示富含多酚的可可影响肾脏血流动力学的机制可能涉及激活肾内一氧化氮合酶。为了进行评估，我们正在测量尿液和血液中一氧化氮合成的代谢产物，并评估用L-NAME阻断一氧化氮合成对肾血供的影响。这是一项研究者发起的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To expose the possibility that the mechanism which polyphenol-rich cocoa influences renal hemodynamics involves activation of intrarenal nitric oxide synthase. To make that assessment, we are measuring the metabolic products of nitric oxide synthesis in urine and blood, and assessing the influence on the renal blood supply of blocking nitric oxide synthesis with L-NAME. This is an investigator initiated study.