CLINICAL EVALUATION OF PORTABLE LACTATE METER IN TYPE GLYCOGEN STORAGE DISEASE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。1型糖原储存病与低血糖和高血乳酸水平相关。目前，患者可以使用便携式手指棒血糖仪监测血糖，但乳酸水平只有在有实验室的临床访问时才能确定。高乳酸水平与该疾病的一些长期并发症有关，在家中监测这些水平的能力将对受影响的个体非常有利。最近，一种便携式血乳酸计lactate - pro已经上市，但尚未进行临床应用测试。我们建议通过比较手指棒和静脉样本在仪表上运行与临床实验室获得的结果来测试乳酸- pro的准确性。具体来说，我们将比较实验室里的静脉样本和仪表上的静脉样本；手指棒样本读数也将与实验室样本进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Glycogen storage disease type 1 is associated with hypoglycemia and high blood lactate levels. Presently, patients may use portable finger stick glucose meters to monitor blood sugars, but lacate levels are only determined during clinical visits with laboratory access. High lactate levels have been associated with several long-term complications of the disease, and the ability to monitor these levels in the home would be greatly advantageous to affected individuals. Recently, a portable blood lactate meter, the Lactate-Pro, has become available, but it has not yet been tested for clinical use. We propose testing the accuracy of the Lactate-Pro by comparing finger stick and venous samples run on the meter to the results obtained by the clinical labs. Speciafically, we will be comparing venous samples run in the lab to venous samples run on the meter; finger stick sample readings will also be compared to laboratory samples.