Collaborative Research: Development and Evaluation of a Miniature Coaxial Ion Trap Mass Analyzer for Portable Chemical Analysis

合作研究：用于便携式化学分析的微型同轴离子阱质量分析仪的开发和评估

• 批准号: 2003667
• 负责人: Daniel Austin
• 金额: $ 16.53万
• 依托单位: Brigham Young University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2003667&HistoricalAwards=false
• 关键词: Collaborative; Research; Development; Evaluation; Miniature

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Drs. Nicholas Taylor and Kristina Lemmer at Western Michigan University and Daniel Austin at Brigham Young University are working to develop a novel miniaturized instrument for field-portable chemical analysis based on a powerful method known as mass spectrometry. Specifically, the team seeks to develop a device capable of more detailed and yet faster analysis than is currently possible in field-portable analyzers. The ability to provide industry and the scientific community with a simple, lightweight, and portable tool capable of rapid in situ chemical measurements can have a societal impact on many areas including biochemistry, pharmacology, environmental monitoring, threat detection, industrial monitoring and quality control, as well as planetary exploration. The work is being conducted by undergraduate and graduate students in chemistry and aerospace engineering, including members of underrepresented groups. This cross-disciplinary collaboration resonates with NSF’s goal to enhance convergence research while inspiring and helping train the next generation of scientists and engineers.Field portable systems equipped with highly miniaturized ion trap mass analyzers will possess the ability to rapidly and reliably make quantitative chemical measurements of a wide range of molecular species. The novel coaxial ion trap being designed and build by the Taylor team utilizes a rectilinear ion guide (RIG) for efficient injection of internally or externally generated ions into a high capacity simplified toroidal ion trap (STorIT) for ion accumulation and storage. Ions of analytical interest stored in the toroidal trapping region are mass selectively injected into a cylindrical ion trap (CIT) nested within the toroidal trapping ring. The process of spatially isolating ions for MSn analysis can be repeated for a range of species without having to repopulate the toroidal trapping region, enhancing analytical efficiency. Since a single mass is injected into the CIT for MSn analysis, there is an inherent reduction in chemical noise which enhances the device’s detection limits and identification confidence. The system is being modeled and experimentally evaluated through a collaborative effort between Western Michigan University and Brigham Young University. Three target applications will allow testing of key performance features: rapid analysis of suspected illegal drug powders, sensitive detection of tracer compounds used in natural gas and petroleum wells, and characterization of semi-volatile compounds in atmospheric aerosols.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学部化学测量和成像项目的支持下，西密歇根大学的Nicholas Taylor和Kristina Lemmer博士以及杨百翰大学的丹尼尔奥斯汀正在努力开发一种新型的小型化仪器，用于现场便携式化学分析，该仪器基于一种强大的方法，即质谱法。具体来说，该团队寻求开发一种能够比目前现场便携式分析仪更详细、更快分析的设备。 为工业和科学界提供能够快速进行原位化学测量的简单、轻便和便携式工具的能力可以对许多领域产生社会影响，包括生物化学、药理学、环境监测、威胁检测、工业监测和质量控制以及行星探索。这项工作正在进行的本科生和研究生在化学和航空航天工程，包括成员的代表性不足的群体。 这种跨学科的合作与NSF的目标相呼应，即加强聚合研究，同时激励和帮助培养下一代科学家和工程师。配备高度小型化离子阱质量分析仪的现场便携式系统将具备快速可靠地对各种分子种类进行定量化学测量的能力。Taylor团队正在设计和建造的新型同轴离子阱利用直线离子导向器（RIG）将内部或外部产生的离子有效注入到高容量简化环形离子阱（STorIT）中，以进行离子积累和存储。存储在环形捕获区域中的分析感兴趣的离子被质量选择性地注入到嵌套在环形捕获环内的圆柱形离子阱（CIT）中。 可以对一系列物质重复空间隔离离子以进行MSn分析的过程，而不必重新填充环形捕获区域，从而提高分析效率。由于将单个质量注入CIT进行MSn分析，因此化学噪声固有降低，这提高了设备的检测限和识别置信度。该系统正在通过西密歇根大学和杨百翰大学之间的合作努力进行建模和实验评估。三个目标应用程序将允许测试的关键性能特征：可疑非法毒品粉末的快速分析，天然气和石油威尔斯井中使用的示踪剂化合物的灵敏检测，以及大气气溶胶中半挥发性化合物的表征。该奖项反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

项目成果

Varying the aspect ratio of toroidal ion traps: Implications for design, performance, and miniaturization

• DOI: 10.1016/j.ijms.2021.116703
• 发表时间: 2021-09-11
• 期刊: INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
• 影响因子: 1.8
• 作者: Hettikankanange, Praneeth M.;Austin, Daniel E.
• 通讯作者: Austin, Daniel E.

Simplified coaxial ion trap: Simulation-based geometry optimization, unidirectional ejection, and trapping conditions

简化的同轴离子阱：基于仿真的几何优化、单向喷射和捕获条件

• DOI: 10.1016/j.ijms.2022.116801
• 发表时间: 2022
• 期刊: International Journal of Mass Spectrometry
• 影响因子: 1.8
• 作者: Gamage, Radhya W.;Hettikankanange, Praneeth M.;Lyman, Kyle D.;Austin, Daniel E.;Taylor, Nicholas R.
• 通讯作者: Taylor, Nicholas R.