PHENOTYPE GENOTYPE PROJECT IN ADDICTION AND MOOD DISORDERS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这个成瘾和情绪障碍的表型-基因型项目的总体目标是了解大脑回路改变的遗传基础，这些改变赋予了对兴奋剂依赖和抑郁的易感性或抗性。该项目的初始阶段将在大家庭的多个成员中描述这些疾病的基于神经成像的标记，以确定其亲缘性/遗传性。一旦获得进一步的资金，该项目的下一阶段将寻求确定成瘾和抑郁的遗传基础。为了获得成瘾和抑郁的基于电路的内表型，我们将使用形态测量和功能磁共振成像（mMRI和fMRI）。本研究旨在描述900名受试者的一组精神表型和基于神经回路的内表型。一旦与这些神经精神疾病相关的内表型标记物被确定，我们就会寻找遗传多态性的联系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this Phenotype-Genotype Project in Addictions and Mood Disorders is to understand the genetic bases for the brain circuitry alterations conferring susceptibility or resistance to stimulant dependence and depression. The initial phase of this project will characterize neuroimaging-based markers of these illnesses in multiple members of extended families so as to establish their familiality/heritability. A subsequent phase of this project will, once further funding is obtained, seek to identify the genetic bases of addiction and depression. To derive circuitry-based endophenotypes for addiction and depression, we will employ morphometric and functional magnetic resonance imaging (mMRI and fMRI). This study aims to delineate a set of psychiatric phenotypes and circuitry-based endophenotypes in 900 subjects. Once endophenotypic markers associated with these neuropsychiatric diseases have been characterized, we will then look to link genetic polymorphisms.