OSTEOARTHRITIS INITIATIVE: A KNEE STUDY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。大约有2070万美国人患有医生诊断的骨关节炎（OA），还有更多的人患有未诊断或亚临床疾病。目前评价OA的技术是X线片。然而，该方法对早期OA病理不敏感。需要其他成像方法和/或生物标志物，能够在OA变得放射学明显的阶段之前检测OA。这项多中心研究的目的是开发和评估新的、更敏感的技术，用于评估早期OA，并评估可能作为早期骨关节炎疾病指标的OA潜在生物标志物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Approximately 20.7 million Americans have physician diagnosed osteoarthritis (OA), and many more have undiagnosed or subclinical disease. The present technique of OA evaluation is the radiograph. However, this method is insensitive to early OA pathology. Other imaging methods and/or biomarkers that capable of detecting OA prior to the stage when it becomes radiographically evident are needed. The purpose of this multicenter study is to develop and assess new, more sensitive technologies for assessing early stages of OA, and to evaluate potential biomarkers of OA that may be indicators of early osteoarthritic disease.