CHILDHOOD ASTHMA MANAGEMENT PROGRAM - CONTINUATION STUDY - PHASE 2 (CAMP CS/2)

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这是一项对参加儿童哮喘管理项目（CAMP）的儿童进行的为期4年的观察性随访研究。CAMP是一项多中心随机临床试验，旨在确定3种治疗（沙丁胺醇、沙丁胺醇+吸入性类固醇、沙丁胺醇+吸入性非类固醇）对5-13岁轻中度哮喘儿童的影响。本研究的假设是，在CAMP期间使用吸入性糖皮质激素不会有益于肺功能，但会降低气道反应性，不会影响身高和骨密度，并会减少症状的持续、缓解和复发，从而减少对药物的需求。此外，下呼吸道症状、过敏、血嗜酸性粒细胞增多、气道反应性和个人吸烟的增加会降低肺功能。最后，某些基因型变异将与哮喘引起的肺功能生长受损相关。将检查三个特定目的，包括1）下呼吸道症状、过敏、血嗜酸性粒细胞增多、气道反应性和个人吸烟对青年期达到的肺功能和反应性水平的影响2）肺功能和气道反应性、过敏、嗜酸性粒细胞增多症和个人吸烟对下呼吸道症状的影响; 3）与低FEV 1/CAMP受试者与正常受试者的FVC。 这项研究将是第一项确定青年期哮喘结局决定因素的儿童哮喘研究，也是第一项检查强效抗炎药强化治疗对结局影响的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a 4-year observational follow-up study of children enrolled in the Childhood Asthma Management Program (CAMP). CAMP was a multicenter randomized clinical trial designed to determine the effects of three treatments (albuterol, albuterol plus inhaled steroids, albuterol with inhaled non steroids) in children age 5-13 years with mild to moderate asthma. The hypothesis of this study is that inhaled corticosteroids used during CAMP will not benefit lung function but will decrease airway responsiveness, will not affect height and bone density, and will reduce persistence, remission and relapse of symptoms with resultant need of medication. Furthermore, increase in lower respiratory symptoms, allergy, blood eosinophilia, airway responsiveness, and personal smoking will decrease lung function. Finally, certain genotypic variants will be associated with impairment of growth of lung function caused by asthma. Three Specific Aims will be examined including 1) the effects of lower respiratory symptoms, allergy, blood eosinophilia, airway responsiveness, and personal smoking on attained level of lung function and reactivity in young adulthood 2) effects of lung function and airway reactivity, allergy, eosinophilia and personal smoking on lower respiratory symptoms in young adulthood and 3) factors associated with low FEV1/FVC in CAMP subjects versus normal subjects. This study will be the first study of childhood asthma to define the determinants of outcomes in young adulthood and the first to examine the effects of intensive treatment with potent anti-inflammatory agents on outcomes.