REDUCED PHOSPHATE INTAKE IN "NORMO-PHOSPHATEMIC" CHRONIC KIDNEY DISEASE PATIENTS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是：(1)确定即使没有高磷血症，磷酸盐负荷在继发性甲状旁腺功能亢进的发展中的首要地位；(2)开发一种治疗策略的试验数据，通过增加内源性骨化三醇水平来改善继发性甲状旁腺功能亢进的发展，骨化三醇本身和降低的磷酸盐水平可能是潜在的生存因素。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purposes of this proposal are to (1) establish the primacy of phosphate loading, even without hyperphosphatemia, in the development of secondary hyperparathyroidism and (2) develop pilot data of a treatment strategy that manipulates phosphate loading in an effort to ameliorate the development of secondary hyperparathyroidism by increasing endogenous calcitriol levels, which itself along with decreased phosphate levels may be potential survival factors.