PLASMA FREE AND TOTAL HOMOCYSTEINE FOLLOWING AN ORAL METHIONINE LOAD

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。同型半胱氨酸是一种从蛋氨酸中提取的物质，蛋氨酸是蛋白质的一部分，存在于我们吃的大多数食物中。同型半胱氨酸被认为是导致或加重心脏病的重要因素。同型半胱氨酸导致动脉损伤的确切方式尚不清楚，但人们认为它会损害动脉。蛋白质餐后，血液中同型半胱氨酸水平升高，并与血管异常有关。我们希望确定餐后游离同型半胱氨酸与结合同型半胱氨酸的比例是否上升。由于很难对蛋白质摄入量进行标准化，因此使用了蛋氨酸片的标准化测试。我们将比较心脏病患者与正常志愿者蛋氨酸负荷后游离同型半胱氨酸的升高，并研究血管损伤的标记物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Homocystiene is a substance that is derived from methionine which is a part of protein that is present in most foods that we eat. Homocysteine is thought to be important in causing or worsening heart dieease. The exact way in which homocysteine causes dmage is not known but it is thought to damage arteries. Following a protein meal, blood levels of homocysteine rise and is associated with abnormalities in blood vessels. We wish to determine whether the proportion of free homocysteine to bound homocysteine rises following a meal. Since it is difficult to standardize protein intake a standardized test involving methionine tablets is used. We will be comparing the rise in free homocysteine following methionine load in patients with heart disease with normal volunteers and study markers of blood vessel damage.