IDENTIFICATION OF DIABETIC NEPHROPATHY RISK GENES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。确定糖尿病肾病（ND）的相关基因及其与终末期肾病（ESRD）的连锁关系（如有）。第二个目的是鉴定可能与DN基因相同或不同的肾病基因。具体目标是：组织一个多中心的联盟，在非裔美国人（AA）、墨西哥裔美国人（MA）、高加索人/欧洲裔美国人（EA）和美洲原住民（NA）的表型范围内招募参与者;使用受影响的相对对（阿普）、不一致的相对对（DRP）和通过混合连锁不平衡（MALD）连锁分析作图来扫描基因组中的连锁染色体区域，和传播不平衡测试（TDT），以评估候选基因在这些地区的连锁证据，并使用环境数据作为指导可能的风险因素对遗传易感性的影响。这是一项临床研究横断面研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To identify genes responsible for diabetic nephropathy (ND) and their linkage relationships, if any, to ESRD. A secondary aim is to identify nephropathy genes which may be the same or distinct from the genes of DN. Specific aims are to: organize a multi-centered consortium to undertake the recruitment of participants within a phenotypic range African-American (AA), Mexican-American (MA), and Caucasian/European Americans (EA), and Native Americans (NA); use affected relative pair (ARP), discordant relative pair (DRP), and mapping by admixture linkage disequilibrium (MALD) linkage analyses to scan the genome for linked chromosomal regions, and the transmission disequilibrium test (TDT) to evaluate candidate genes in those regions with evidence for linkage; and use environmental data as a guide for possible risk factor effects on genetic susceptibility. This is a clinical research cross sectional study.