HIV-RELATED PROTEINURIA AND ENDOTHELIAL DYSFUNCTION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项前瞻性观察性研究将评估成人HIV感染者蛋白尿与现存和进行性内皮功能障碍之间的关系。有和没有蛋白尿的受试者在基线和24个月后再次进行臂部血流介导的扩张和其他心血管危险因素的比较。共有72名受试者，36名有持续性蛋白尿的受试者和36名无蛋白尿症的受试者，预计将参加这项研究，并进行大约30个月的跟踪调查。研究程序将包括生命体征测量、人体测量学、尿液和血液测试以及臂动脉超声测量。受试者将被要求完成关于他们的锻炼活动和身体形象的问卷调查。参与者将被要求在每次超声测量之前的五天内停止服用任何阿司匹林或阿司匹林类药物、糖尿病药物、高血压药物和高胆固醇药物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This prospective observational study will evaluate the associations between proteinuria and existing and progressive endothelial dysfunction in adult, HIV-infected individuals. Subjects with and without proteinuria will have their brachial-flow mediated dilation and other cardiovascular risk factors compared at baseline and again 24 months later. A total of 72 subjects, 36 subjects with persistent proteinuria and 36 non-proteinuric subjects, are expected to enroll in the study and be followed for approximately thirty months. Study procedures will include vital sign measurements, anthropometrics, urine and blood tests, and brachial artery ultrasound measurements. Subjects will be asked to complete questionnaires about their exercise activities and body image. Participants will be asked to stop taking any aspirin or aspirin like medications, diabetes medications, high blood pressure medications, and high cholesterol medications for five days before each of the ultrasound measurements.