NEUROLOGICAL PREDICTORS OF HUNTINGTON DISEASE (PREDICT-HD)

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。疾病发作是治疗试验的一个重要结果衡量标准，试验涉及健康的人，他们有表现出疾病的已知风险。该项目的主要目的是在出现临床明显的运动症状之前，确定亨廷顿病(HD)的神经生物学和神经行为标记物的特征。受试者将是年龄在30-55岁之间的男性和女性，他们由于父母的影响而有患HD的风险，并接受过HD的基因检测(425例CAG Repeat&gt；39和75例CAG Repeat&lt；30)。受试者每年接受一次检查，为期4年。评估将包括神经学检查、广泛的神经心理测试、心理评估和磁共振成像。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Onset of disease is a vital outcome measure for therapeutic trials involving healthy persons who are at known risk for manifesting disease. The primary aim of this project is to characterize neurobiological and neurobehavioral markers of Huntington Disease (HD) prior to the development of clinically manifest motor symptoms. Subjects will be men and women ages 30-55 who are at risk for HD by virtue of having an affected parent and who have undergone genetic testing for HD (425 with CAG repeat > 39 and 75 with a CAG repeat < 30). Subjects will be examined once a year for 4 years. Assessment will include a neurological examination, extensive neuropsychological testing, psychological assessment, and magnetic resonance imaging.