NEUROLOGICAL PREDICTORS OF HUNTINGTON DISEASE (PREDICT-HD)

亨廷顿病的神经学预测因素 (PREDICT-HD)

• 批准号: 7606386
• 负责人: Kimberly Andrea Quaid
• 金额: $ 0.33万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606386
• 关键词: Affect; Age; CAG repeat; Computer Retrieval of Information on Scientific Projects Database; Development; Disease; Funding; Genetic screening method; Grant; Huntington Disease; Institution; Magnetic Resonance Imaging; Motor; Neurobiology; Neurologic; Neurologic Examination; Onset of illness; Outcome Measure; Parents; Persons; Psychological Tests; Research; Research Personnel; Resources; Risk; Source; Symptoms; Therapy Clinical Trials; United States National Institutes of Health; Woman; men; neurobehavioral

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Onset of disease is a vital outcome measure for therapeutic trials involving healthy persons who are at known risk for manifesting disease. The primary aim of this project is to characterize neurobiological and neurobehavioral markers of Huntington Disease (HD) prior to the development of clinically manifest motor symptoms. Subjects will be men and women ages 30-55 who are at risk for HD by virtue of having an affected parent and who have undergone genetic testing for HD (425 with CAG repeat > 39 and 75 with a CAG repeat < 30). Subjects will be examined once a year for 4 years. Assessment will include a neurological examination, extensive neurophyschological testing, psychological assessment, and magnetic resonance imaging.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 疾病的发作是涉及涉及健康疾病风险的健康人的治疗试验的重要结果措施。 该项目的主要目的是表征亨廷顿疾病（HD）的神经生物学和神经行为标记，然后才能发展出临床表现运动症状。 受试者将是30-55岁的男性和女性，他们因患有受影响的父母而受到HD的风险，并且对HD进行了基因测试（425，CAG重复> 39和75，CAG重复<30）。 每年将检查一次受试者4年。 评估将包括神经系统检查，广泛的神经生理测试，心理评估和磁共振成像。