VITAMIN D SUPPLEMENTATION TO REDUCE GINGIVAL INFLAMMATION IN GINGIVITIS IN HUMAN

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。原理：在实验室和动物研究中已经发现维生素D的抗炎作用。假设：口服维生素D可以降低实验性牙周炎的易感性。设计：这是一项随机、安慰剂对照、双盲、平行分组的先导性临床试验。我们计划招募48名健康志愿者，他们将被随机分为维生素D2组(每周两次，50000国际单位，持续5周)或安慰剂组(每组24人)。随机化2周后，受试者将在3周内不采取口腔卫生措施。牙周炎对菌斑堆积的反应程度将在不同组之间进行比较。此外，我们还将评估血清25-OHD水平与牙周炎的发生以及血清炎症标志物之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rationale: Anti-inflammatory effects of Vitamin D have been found in laboratory and animal studies. Hypothesis: Oral supplementation with vitamin D can reduce the susceptibility to experimental gingivitis. Design: This is a randomized, placebo-controlled, double-blind, parallel group pilot clinical trial. We plan to recruit 48 healthy volunteers who will be randomized to vitamin D2 (50,000 IU twice per week for 5 weeks) or placebo (n=24 per group). 2 weeks after randomization, subjects will abstain from oral hygiene measures for 3 weeks. The extent to which gingivitis develops in response to plaque accumulation will be compared between groups. Furthermore, we will evaluate the association between serum levels of 25-OHD and the development of gingivitis as well as serum markers of inflammation.