GENOTYPE-PHENOTYPE INTERACTIONS IN SEVERE ASTHMA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。在美国，哮喘是一种常见的慢性肺部疾病，影响着超过1700万人。它是一种气道炎症，其病因尚不完全清楚。大约10%的哮喘患者有持续症状的“严重哮喘”，尽管使用高剂量吸入或口服皮质类固醇（减少气道炎症的药物）。这组研究检查了哮喘患者肺部的基因和细胞/液体，以更好地理解为什么哮喘在某些人中更严重

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asthma is a common chronic lung disease in the United States, affecting more than 17 million persons. It is an inflammatory condition of the airways whose cause is not completely understood. Approximately 10% of asthmatics have "severe asthma" with continuous symptoms despite the use of high doses of inhaled or oral corticosteroids (medications to reduce inflammation in the airways). This group of studies examines genes and cells/fluid from lungs of people with asthma to better understand why asthma is more severe in some peo