DIETARY OXALATE LOADING AND KIDNEY STONE FORMATION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。肾结石的形成是一个常见的医学问题。大多数结石是由钙和草酸盐组成的。草酸排泄到尿液中是形成这种结石所必需的。尿液中相当数量的草酸来自饮食来源。这项研究的目的是建立一种方案来评估草酸钙结石患者和正常受试者的以下指标：(I)胃肠道草酸盐吸收；(Ii)不同饮食草酸盐剂量后，尿中草酸盐相对于肌酐的排泄量；(Iii)剂量后体内发生的脂肪酸氧化量。这个方案应该有助于确定这两组之间的差异，这将有助于未来对草酸钙结石形成的评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Kidney stone formation is a common medical problem. The majority of stones are composed of calcium and oxalate. The excretion of oxalate into urine is necessary for such stones to develop. A significant amount of the oxalate in urine is derived from dietary sources. The aim of this study is to develop a protocol to assess the following in calcium oxalate stone formers and normal subjects: (i) gastrointestinal oxalate absorption; (ii) the amount of oxalate excreted in urine relative to creatinine after varying dietary oxalate doses; (iii) the amount of fatty acid oxidation that occurs in the body after the dose. This protocol should assist in identifying differences between these two groups which will help in the future evaluation of calcium oxalate stone formers.