A LONGITUDINAL STUDY OF MILD COGNITIVE IMPAIRMENT IN MS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。认知功能障碍是多发性硬化症致残的主要原因，造成了巨大的社会经济和人际关系损失。不幸的是，多发性硬化症的认知障碍过程尚不清楚。这项研究将特别关注目前表现出可测量的认知缺陷的患者，他们仍然从事职业和社会责任。虽然轻度认知障碍（MCI）一词已被用于识别有阿尔茨海默病发展风险的老年患者，但我们相信MCI的概念可以应用于一组特定的多发性硬化症认知障碍患者。本项目的目标是评估接受标准临床治疗的多发性硬化症患者的认知恶化过程，并确定这种认知衰退的神经放射学和临床相关性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cognitive dysfunction is a leading cause of disability in MS, exacting a tremendous socioeconomic and interpersonal toll. Unfortunately, the course of cognitive impairment in MS remains unclear. This study will focus specifically on patients currently exhibiting measurable cognitive deficits who are still engaged in occupational and social responsibilities. While the term mild cognitive impairment(MCI) has been used to identify elderly patients at risk for the development of Alzheimers disease, we believe the concept of MCI can be applied to a specific group of cognitive impaired patients with MS. The goal of this project is to evaluate the course of cognitive deterioration in MS patients receiving standard clinical care and to identify neuroradiological and clinical correlates of this cognitive decline.