ORAL IMMUNE DYSFUNCTION AND ORAL INFECTIOUS DISEASE IN HIV INFECTION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这是一项研究，旨在确定艾滋病病毒是否会影响口腔免疫系统，以及这如何导致口腔感染（鹅口疮、疣、溃疡、口干、牙周炎）的易感性。本研究旨在通过研究hiv阳性和hiv阴性人群的免疫系统，以及有无口腔感染，更好地理解hiv感染者容易发生口腔感染的原因。该研究将调查女性对hiv阳性人群中常见的几种口腔感染的口腔和血液免疫以及阴道免疫，包括口腔酵母菌感染、口腔溃疡、口腔疣、毛状白斑、溃疡性牙周炎和口炎。将对有和没有口腔感染的艾滋病毒阳性和艾滋病毒阴性个体的血细胞或阴道洗液（仅限女性）与口腔洗液或口腔活组织检查中的免疫反应或缺乏免疫反应进行比较。这将有助于显示存在的免疫类型，以及感染艾滋病毒的个体是否缺乏口腔免疫状态，从而容易发生口腔感染。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a research study to identify whether the AIDS virus affects the immune system in the mouth, and how this creates susceptibility in infections in the mouth (oral thrush, warts, ulcers, dry mouth, periodontitis). This research study aims to better understand why HIV-infected individuals are prone to oral infections through studying the immune system of HIV-positive and HIV-negative people, with and without oral infections. The study will investigate the oral and blood immunity, as well as vaginal immunity in women, to several oral infections common in HIV-positive persons, including oral yeast infections, oral ulcers, oral warts, hairy leukoplakia, ulcerative periodontitis, and stomatitis. Immune responses, or lack thereof, in the blood cells or vaginal wash (women only) compared to that in oral washes or oral biopsies will be compared between HIV-positve and HIV-negative individuals with and without oral infections. This will help show the type of immunity present and whether individuals with HIV infection are deficient in their oral immune status such that they are prone to oral infections.