EFFECT OF ACUTE ADMINISTRATION OF GHRELIN [60]

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。在对非自然ghrp进行了20年的研究之后，研究最终发展到分离出被称为ghrelin的天然激素。Ghrelin由28个氨基酸组成，包括一个o -n-辛酸Ser3残基，这是生长激素释放所必需的。这种激素是下丘脑和垂体中表达的生长激素分泌激素（GHS）受体的天然配体。胃促生长素在全身和脑室内给药后刺激脉冲性生长激素释放。它主要在胃和上胃肠道合成，潜在地刺激生长激素和食物摄入。本研究的具体目的是研究胃饥饿素的促垂体作用并检验其安全性。据推测，胃促生长素在生长激素释放中起主要作用，胃、食欲和新陈代谢之间可能存在重要联系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. After 20 years of work on the unnatural GHRPs, studies finally evolved into the isolation of the natural hormone designated ghrelin. Ghrelin consists of 28 amino acids including an O-n-octanolyated Ser3 residue which is essential for GH release. This hormone is the natural ligand for the growth hormone secretagogue (GHS) receptor expressed in the hypothalamus and pituitary. Ghrelin stimulates pulsatile GH release following systemic as well as intracerebroventricular administration. It is predominantly synthesized in the stomach and upper gastrointestinal tract and potentially stimulates GH as well as food intake. The specific aim of this study is to investigate the hypophysiotropic actions of ghrelin and to test its safety. It is postulated that ghrelin plays a major role in GH release and that there may be important links between the stomach, appetite and metabolism.