A RANDOMIZED, PLACEBO CONTROLLED,DOUBLE BLIND,PROSPECTIVE STUDY OF CO-ENZYME Q10

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项研究的目的是确定与使用降低胆固醇的“他汀类药物”相关的副作用是否可以通过一种叫做辅酶Q-10的天然物质来改善。降低胆固醇很重要，可以将患中风或心脏病的风险降低30%左右。然而，血液测试显示，他汀类药物可能会对肝脏和肌肉造成损害。一些患者在没有异常血液检查的情况下也会抱怨肌肉疼痛、肿胀、虚弱或疲劳。这项研究希望确定是否提供被他汀类药物阻断的辅酶Q-10可以改善这些副作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine if side effects associated with the use of cholesterol lowering "statins" can be improved with a naturally occurring substance called coenzyme Q-10. Cholesterol lowering is important and may reduce the risk of having or dying from a stroke or heart attack by about 30%. However, statins may cause damage to the liver and muscles,as measured by blood tests. Some patients also complain of muscle aches,swelling,weakness or fatigue without abnormal blood tests. This study hopes to determine if providing coenzyme Q-10,which is blocked by statins,could improve these side effects.