PAROXETINE & SILDENAFIL ON PHARMACOKINETICS OF METOPROLOL, CARVEDILOL, & ATENOLO

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。有许多药物相互作用被认为会发生，但没有得到很好的描述。这包括一类称为β受体阻滞剂的药物（对于本研究，这些药物将包括美托洛尔，美托洛尔缓释，卡维地洛和阿替洛尔）与其他两种药物之间的药物相互作用，一种称为帕罗西汀（Paxil）的抗抑郁药和一种称为西地那非（Viagra）的性功能障碍药物。本研究将招募正常志愿者。将受试者随机分配至研究组。主要结果将是当与相互作用的药物（Paxil和Viagra）一起使用时，不同的β受体阻滞剂如何从体内消除，以及相互作用的药物如何影响β受体阻滞剂对心率和血压的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are many drug interactions that are thought to occur but are not well described. This includes drug interactions between a class of drugs called beta-blockers (for this study these drugs will include metoprolol, metoprolol extended release, carvedilol, and atenolol) and two other drugs, an antidepressant called paroxetine (Paxil) and a drug for sexual dysfunction called sildenafil (Viagra). For this study, normal volunteers will be recruited. Subjects will be randomly assigned to study groups. The primary outcomes will be changes in how the different beta-blockers are eliminated from the body when administered with the interacting drugs (Paxil and Viagra) and how the interacting drugs may affect beta blocker effects on heart rate and blood pressure The results of this study will lead to a better understanding on how to use these drugs together to treat patients more safely.