COGNITIVE AND PHARMACOLOGICAL MODULATION OF THE HUMAN NEUROENDOCRINE STRESS AXIS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。这个研究项目将有助于我们了解大脑如何调节我们对压力反应所涉及的激素和行为。我们将探索一种称为胆囊收缩素的特定激素在帮助控制其他激素释放方面的自然作用。我们还将探索可能影响这种激素释放的心理因素的作用。 参与者将是一个“对照组”的人谁没有特别的问题，焦虑，抑郁症，或压力相关的障碍。将有大约60名年龄在18至45岁之间的受试者，他们在医学上是健康的，没有服用药物或药物。受试者将在两个下午入住密歇根大学医院的综合临床研究中心。他们将在手臂的静脉中放置静脉输液管约4小时。我们将通过这条线抽取血液样本，并使用它给他们注射一种名为五肽胃泌素的药物或安慰剂（非活性物质）。五肽胃泌素是消化激素胃泌素和胆囊收缩素的合成版本，可以刺激体内某些细胞释放其他激素。我们最感兴趣的是皮质醇和促肾上腺皮质激素，这两种激素的释放是由五肽胃泌素触发的，人们在试图科普挑战或压力时也会分泌这两种激素。我们将使用不同类型的指令来研究思想和感受如何影响这些激素的释放。受试者接受的指导将随机确定。该研究有助于我们更好地了解胆囊收缩素和心理因素在人类应激反应系统中的作用。我们希望这项工作将有助于制定更好的压力管理方法。我们还希望它能帮助我们开发出一些模型，用于研究不同精神疾病中的人类应激反应系统，或许还能帮助我们寻找其中一些疾病的原因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research project will contribute to our understanding of how the brain regulates the hormones and behaviors involved in our responses to stress. We will be exploring the natural role of a specific hormone, called cholecystokinin, in helping to control the release of other hormones. We will also be exploring the role of psychological factors that might effect this hormone release. Participants will be a "control group" of people who do not have particular problems with anxiety, depression, or stress-related disorders. There will be about 60 subjects between 18 and 45 years of age, who are medically healthy and are not taking medication or drugs. Subjects will be admitted on two afternoons to the General Clinical Research Center at the University of Michigan Hospital. They will have an intravenous line in place in a vein in their arm for about 4 hours. We will draw blood samples through this line and will also use it to give them either a dose of a medication called pentagastrin or a placebo (inactive substance) infusion. Pentagastrin is a synthetic version of the digestive hormones gastrin and cholecystokinin, which can stimulate the release of other hormones from certain cells in the body. We will be most interested in cortisol and adrenocorticotropin, two hormones whose release is triggered by pentagastrin and that people also secrete when attempting to cope with a challenge or stressor. We will be using different types of instructions to also study how thoughts and feelings can effect release of these hormones. Which instructions subjects receive will be determined randomly. The study may help us better understand the role of cholecystokinin and psychological factors in human stress response systems. We hope this work will contribute to the development of improved approaches to the management of stress. We also hope that it will help us to develop models that will be useful in studying the human stress response system in different psychiatric disorders and perhaps help us search for the causes of some of these disorders.