EFFECT OF AGE ON HEPATIC GLUCOSE PRODUCTION AND BETA CELL FUNCTION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。饮用糖溶液后血糖升高（或葡萄糖耐量降低）在60岁以上的人群中很常见。糖耐量受损的人患2型糖尿病（或成人发病糖尿病）的风险增加。胰岛素是人体分泌的一种帮助控制血糖的激素。患有糖耐量受损和糖尿病的人可能无法产生足够的胰岛素，也可能在肝脏中产生过多的糖。这项研究的目的是观察胰岛素分泌量和肝脏分泌糖的变化是否会导致进食后血糖升高。糖耐量受损的年轻人和老年人将服用二甲双胍或类似的看似无效的片剂（安慰剂）3个月。二甲双胍是一种用于治疗2型糖尿病患者的药丸，它可以减少肝脏产生的糖量，降低血糖。在开始服药前和3个月治疗期结束时将进行测试，以查看进食后血糖有多高，肝脏产生多少糖，身体使用胰岛素的情况如何，以及身体产生多少胰岛素。决定给一个人服用安慰剂还是二甲双胍将是随机决定的，就像抛硬币一样。这项研究可以帮助我们理解为什么老年人患糖耐量受损和糖尿病的风险增加。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Increased blood sugars after drinking a sugar solution (or impaired glucose tolerance) is common in people over age 60. People with impaired glucose tolerance are at increased risk to develop type 2 diabetes (or adult onset diabetes). Insulin is a hormone the body makes to help control blood sugars. People with impaired glucose tolerance and diabetes may not make enough insulin and may also make too much sugar in the liver. The purpose of this research study is to see if changes in how much insulin people make and how much sugar the liver makes contributes to the development of increased blood sugars after eating. Young and older people with impaired glucose tolerance will take metformin or a similar appearing but inactive tablet (placebo) for 3 months. Metformin is a pill used to treat people with type 2 diabetes, and it decreases how much sugar the liver makes and lowers blood sugars. Tests will be done before starting on the medicine and at the end of the 3 month treatment period to see how high blood sugars after eating are, how much sugar the liver makes, how well the body uses the insulin it makes, and how much insulin the body makes. The decision about whether a person is given placebo or metformin will be decided randomly, like when a coin is flipped. This study may help us understand why older people are at increased risk to develop impaired glucose tolerance and diabetes.