EFFECT OF AGE ON HEPATIC GLUCOSE PRODUCTION AND BETA CELL FUNCTION

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Increased blood sugars after drinking a sugar solution (or impaired glucose tolerance) is common in people over age 60. People with impaired glucose tolerance are at increased risk to develop type 2 diabetes (or adult onset diabetes). Insulin is a hormone the body makes to help control blood sugars. People with impaired glucose tolerance and diabetes may not make enough insulin and may also make too much sugar in the liver. The purpose of this research study is to see if changes in how much insulin people make and how much sugar the liver makes contributes to the development of increased blood sugars after eating. Young and older people with impaired glucose tolerance will take metformin or a similar appearing but inactive tablet (placebo) for 3 months. Metformin is a pill used to treat people with type 2 diabetes, and it decreases how much sugar the liver makes and lowers blood sugars. Tests will be done before starting on the medicine and at the end of the 3 month treatment period to see how high blood sugars after eating are, how much sugar the liver makes, how well the body uses the insulin it makes, and how much insulin the body makes. The decision about whether a person is given placebo or metformin will be decided randomly, like when a coin is flipped. This study may help us understand why older people are at increased risk to develop impaired glucose tolerance and diabetes.'