SHORT-TERM EXERCISE, ?-CELL FUNCTION, AND INSULIN RESISTANCE IN OLDER PEOPLE

老年人的短期锻炼、β-细胞功能和胰岛素抵抗

• 批准号: 7376634
• 负责人: ANNETTE M CHANG
• 金额: $ 2.81万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376634
• 关键词: aging; blood; exercise; insulin; insulin sensitivity /resistance; noninsulin dependent diabetes mellitus

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Blood sugars increase with age, and older people are at high risk to develop type 2 diabetes (or adult onset diabetes). Increased blood sugars after drinking a sugar solution (or impaired glucose tolerance) is also common in people over age 60. People with impaired glucose tolerance are at increased risk to develop type 2 diabetes. Insulin is a hormone the body makes to help control blood sugars. People with impaired glucose tolerance and diabetes may not make enough insulin and may not use the insulin that is made as well. Short-term exercise has been shown to improve the body s use of insulin. The purpose of this research study is to see if short-term exercise to improve the body s use of insulin also improves how much insulin is made. This study may help us understand why older people are at increased risk to develop diabetes.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。血糖随着年龄的增长而增加，老年人患2型糖尿病（或成人型糖尿病）的风险很高。在60岁以上的人群中，饮用糖溶液后血糖升高（或葡萄糖耐量受损）也很常见。糖耐量受损的人患2型糖尿病的风险增加。胰岛素是人体分泌的一种帮助控制血糖的激素。患有糖耐量受损和糖尿病的人可能无法产生足够的胰岛素，也可能无法使用所产生的胰岛素。短期运动已被证明可以改善身体对胰岛素的利用。此次研究的目的是，为了提高身体对胰岛素的利用而进行的短期运动是否也能提高胰岛素的分泌量。这项研究可以帮助我们理解为什么老年人患糖尿病的风险增加。