SHORT-TERM EXERCISE, ?-CELL FUNCTION, AND INSULIN RESISTANCE IN OLDER PEOPLE

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Blood sugars increase with age, and older people are at high risk to develop type 2 diabetes (or adult onset diabetes). Increased blood sugars after drinking a sugar solution (or impaired glucose tolerance) is also common in people over age 60. People with impaired glucose tolerance are at increased risk to develop type 2 diabetes. Insulin is a hormone the body makes to help control blood sugars. People with impaired glucose tolerance and diabetes may not make enough insulin and may not use the insulin that is made as well. Short-term exercise has been shown to improve the body's use of insulin. The purpose of this research study is to see if short-term exercise to improve the body's use of insulin also improves how much insulin is made. This study may help us understand why older people are at increased risk to develop diabetes.'