MICROPARTICLES AND SELECTINS IN INFLAMMATORY BOWEL DISEASES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。微粒是炎症期间从白细胞、血小板和血管内皮细胞（内皮细胞）中释放出来的小块细胞。研究发现，患有多发性硬化症、心脏病、血液细菌感染和其他几种炎症很重要的疾病的人体内的微颗粒会增加。微粒似乎有助于白细胞和血小板粘附在炎症部位的血管壁上。这会导致炎症和血液凝固的增加。选择素是一种粘附分子，可以帮助微粒和血细胞粘附在血管壁上。在一些炎症性疾病中，选择性似乎有所增加。微颗粒和选择素在溃疡性结肠炎和克罗恩病等炎症性肠病中的作用尚未得到仔细研究。这项研究将检验(1)炎症性肠病患者血液中的微粒和选择素是否增加；(2)炎症性肠病患者血液中的微粒和选择素是否比病情较轻的人更多。如果是这样的话，减少血液中的微粒或选择素的治疗可能对炎症性肠病有益。我们将邀请60名溃疡性结肠炎患者（20名轻度，20名中度，20名严重疾病活动），60名克罗恩病患者（20名轻度，20名中度，20名严重疾病活动），以及30名在胃肠道诊所无炎症性疾病，感染或活动性癌症的患者参加。每位受试者将被要求填写一份人口统计表，如果他们患有炎症性肠病，还将填写一份疾病活动表。然后我们将抽取6毫升血液（约1茶匙）用于测量微粒和选择。如果他们要抽血进行临床测试，我们会同时抽血，这样他们就不必抽血两次了。到那时，他们对研究的参与就完成了。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Microparticles are small pieces of cells that are released from white blood cells, platelets, and the cells that line blood vessels (endothelial cells) during inflammation. Microparticles have been found to be increased in people with multiple sclerosis, heart attacks, bacterial infections in the blood, and several other diseases in which inflammation is important. Microparticles appear to help white blood cells and platelets stick to the walls of blood vessels in areas of inflammation. This can result in increased inflammation and blood clotting. Selectins are adhesion molecules that help microparticles and blood cells stick to blood vessel walls. Selectins appear to be increased in some inflammatory diseases. Microparticles and selectins have not been carefully studied in inflammatory bowel diseases like ulcerative colitis and Crohns disease. This study will examine (1) whether people with inflammatory bowel disease have increased microparticles and selectins in their blood and (2) whether people who are more sick with inflammatory bowel disease have more microparticles and selectins in their blood than people who are less sick. If this is the case, treatments that reduce microparticles or selectins in the blood might be beneficial in inflammatory bowel diseases. We will ask 60 patients with ulcerative colitis (20 with mild, 20 with moderate, and 20 with severe disease activity), 60 patients with Crohns disease (20 with mild, 20 with moderate, and 20 with severe disease activity), and 30 patients at the GI clinic with no inflammatory disease, infection, or active cancer to participate. Each subject will be asked to fill out a demographics form, and a disease activity form if they have inflammatory bowel disease. We will then draw 6 mL of blood (about 1 teaspoon) for the measurement of microparticles and selectins. If they are going to have a blood draw for clinical testing, we will do it at the same time, so that they do not have to have two blood draws. Their participation in the study will then be complete.