STUDY OF ENDOTHELIAL DYSFUNCTION AND INSULIN RESISTANCE IN HIV-INFECTED PATIENTS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。目前，对于在接受高效抗逆转录病毒治疗（HAART）的HIV感染患者中观察到的心血管风险增加、胰岛素抵抗和体脂变化的总体临床相关性存在争议。有一个很大的需要了解的演变，内皮功能障碍和胰岛素抵抗的HAART。这项研究将量化多达60名接受HAART的HIV感染男性和女性的内皮功能、胰岛素抵抗、脂肪分布和心血管疾病风险终点的纵向变化。将使用肱动脉反应性试验、血管/内皮功能的血清生物标志物、2小时口服葡萄糖耐量试验和双能X线吸收测定法（全身DEXA）测量这些参数。受试者将通过GCRC和心血管研究实验室接受此测试。这些检查将在入组（基线）时进行，并在3年随访期间每年进行一次。预计患者的内皮功能将在3年内下降至少5%。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Currently there is debate as to the overall clinical relevance of the increased cardiovascular risk, insulin resistance, and body fat changes observed in HIV-infected patients on highly active antiretroviral therapy (HAART). There is a great need to understand the evolution of endothelial dysfunction and insulin resistance in HAART. This study will quantify longitudinal changes in endotheilia funciton, insulin resistance, fat distribution, and cardiovascular disease risk endpoints in up to 60 HIV-infected men and women receiving HAART. These parameters will be measured using brachial artery reactivity testing, serum biomarkers of vascular/endothelial function, 2-hr. oral glucose tolerance testing, and dual energy x-ray absorptiometry (whole-body DEXA). Participants will undergo this testing through the GCRC and the Cardiovascular Reseaach Lab. These tests will occur upon enrollment (baseline) and at yearly intervals for 3 years of follow-up. It is expected that endothelial function in patients will decline by at least 5% over 3 years.