P-GLYCOPROTEIN AND RENAL CLEARANCE OF ANTIBIOTICS IN CF

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的目的是确定CF患者和健康对照者肾脏P-gp对双氯西林清除率的相对贡献。双氯西林单独和联合probenecid（有机阴离子转运抑制剂）和环孢素（P-gp抑制剂）的肾脏清除率将在两组中进行比较。本研究的结果可能为CF患者肾脏对某些化合物的清除改变提供潜在的机制解释。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine the relative contribution of renal P-gp to the clearance of dicloxacillin in patients with CF and healthy controls subjects. The renal clearance of dicloxacillin alone and in combination with probenecid (organic anion transport inhibitor), and cyclosporine (an inhibitor of P-gp) will be compared in both groups. The results of this study may provide a potential mechanistic explanation for the altered renal clearance of certain compounds in patients with CF.