PACTG P1045: MORPHOLOGIC & METABOLIC ABNORMALITIES IN VERTICALLY HIV-INFECTED

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。一项横断面研究，旨在评估垂直感染艾滋病毒的儿童和青年以及未感染的儿童和青年中形态和代谢异常的患病率。这是一项横断面研究，旨在全面评估垂直感染HIV和未感染HIV的儿童和青年中糖代谢、血脂水平、身体成分、脂肪沉积和分布以及骨密度异常的发生率，评估暴露于PI是否与HIV感染的儿童和青年中的代谢和形态异常相关，并根据Tanner分期比较这一人群中异常的发生率。接受抗逆转录病毒治疗的艾滋病毒感染者和7-25岁的未治疗、未感染的受试者将被登记。共有450名受试者将被纳入，按Tanner分期、HIV感染状况和蛋白酶抑制剂治疗进行分层。筛查临床和实验室评估将在一次访问中完成，研究中的临床和实验室评估可能在入选后30天内完成。这些数据对于设计干预试验和研究病理生理机制至关重要。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cross-sectional study designed to evaluate the prevalence of morphologic and metabolic abnormalities in vertically HIV-infected children and youth and uninfected children and youth. This is a cross-sectional study designed to comprehensively evaluate the prevalence of abnormalities in glucose metabolism, serum lipid levels, body composition, fat deposition and distribution, and bone density in vertically HIV-infected and HIV-uninfected children and youth, evaluate whether exposure to PIs is correlated with the metabolic and morphologic abnormalities among HIV-infected children and youth, and compare the prevalence of abnormalities in this population according to Tanner Stage. HIV infected receiving antiretroviral treatment and untreated, uninfected subjects, aged 7-25 years will be enrolled. A total of 450 subjects will be enrolled, stratified by Tanner Stage, HIV infection status, and protease inhibitor therapy. Screening clinical and laboratory evaluations will be completed at one visit and on-study clinical and laboratory evaluations may be completed within 30 days of Entry. These data are critical for designing intervention trials and studies designed to study pathophysiologic mechanisms.