EFFECTS OF ST JOHN?S WORT ON LEVONORGESTREL/EMERGENCY CONTRACEPTION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。本研究将评价一种常用草药圣约翰草（贯叶连翘）在紧急避孕给药方案中对左炔诺孕酮代谢的影响。紧急避孕，如果在无保护的性交后立即采取，可以防止怀孕。圣约翰麦芽汁诱导肝脏中的P450酶系统，并可能导致用于紧急避孕的避孕类固醇代谢增加。这将是一项随机、盲法、临床试验，对四组育龄妇女进行评估，以评估圣约翰草和左炔诺孕酮之间的潜在相互作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will evaluate the effects of a common herbal remedy, St. John's Wort (Hypericum perforatum), on metabolism of levonorgestrel in a dosing regimen for emergency contraception. Emergency contraception, if taken soon after unprotected intercourse, prevents pregnancy. St. John¿s Wort induces the P450 enzyme system in the liver, and may cause increased metabolism of contraceptive steroids used as emergency contraception. This will be a randomized, blinded, clinical trial of four groups of reproductive-aged women to assess the potential interaction between St. John¿s Wort and levonorgestrel.