MECHANISMS OF BONE TURNOVER IN TYPE 1 DIABETES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。观察结果表明，患有1型糖尿病控制不良的儿童和青少年有骨量减少的风险。最近，双能x线骨密度仪（DXA）测量的1型糖尿病青少年腰椎骨密度降低已被报道。我们的研究小组在横断面和纵向研究中观察到，与长期参考人群相比，青少年1型糖尿病患者的胫骨小梁vBMD (p= 0.01)，腰椎和全身骨矿物质含量和密度（p0.05），以及全身骨矿物质含量获取（p0.02）。本研究的具体目的如下：比较1型糖尿病少女和匹配对照（n=6对年龄和成熟匹配的配对）的骨代谢。从这些受试者收集的数据将用于加强根据GCRC第0319号议定书收集的数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Observations suggest that children and adolescents with poorly controlled Type 1 diabetes are at risk for decreased bone mass. Most recently, reduced lumbar BMD measured by dual energy x-ray absorptiometry (DXA) has been reported in Type 1 diabetic adolescents. Our research group has observed lower tibia trabecular vBMD (p=.01), lumbar spine and whole body bone mineral content and density (p0.05), and whole body bone mineral content acquisition (p0.02) in both cross-sectional and longitudinal studies of adolescents with Type 1 diabetes when compared to a secular reference population. This study addresses the following specific aim: To compare bone metabolism in adolescents girls with Type 1 diabetes mellitus and matched controls (n=6 age and maturation-matched pairs). Data collected from these subjects will be used to strengthen data collected under GCRC Protocol # 0319.