TARGETED FORTIFICATION OF BREAST MILK FED TO PREMATURE INFANTS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。极低出生体重婴儿的母乳需要添加蛋白质、矿物质和维生素，因为这些营养素的浓度不足以满足极低出生体重婴儿的高需求。强化的目的是将营养物质浓度提高到能满足正常喂养量所需营养物质的水平。强化还包括以碳水化合物和脂肪的形式添加能量，目的是增加强化牛奶的热量密度，以减少达到足够能量摄入所需的喂养量。这项研究的目的是确定一种新的强化母乳喂养的方法是否能改善VLBW婴儿的营养摄入和生长。这项研究将测试有针对性的强化是可行的假设；与标准强化相比，有针对性的强化可以实现更高的蛋白质和卡路里摄入量；这种有针对性的强化会比标准强化导致更高的体重增加。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Breast milk fed to very-low-birth-weight (VLBW) infants needs to be fortified with protein, mineral and vitamins because concentrations of these nutrients are insufficient to meet the high needs of VLBW infants. The aim of fortification is to raise nutrient concentrations to such levels that nutrient needs are met at usual feeding volumes. Fortification also includes the addition of energy in the form of carbohydrate and fat, with the objective of increasing the caloric density of fortified milk in order to reduce the volume of feedings necessary to achieve adequate energy intakes. The purpose of the study is to determine whether a new method of fortifying breast milk fed to VLBW babies leads to improved nutrient intake and growth. This study will test the hypotheses that targeted fortification is feasible; that targeted fortification achieves higher intakes of protein and calories than standard fortification; and that targeted fortification leads to higher weight gain than standard fortification.