DIETARY ANTIOXIDANT INFLUENCE ON MARKERS OF ATHEROSCLEROSIS AND OXIDATIVE STRESS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。许多观察和实验研究表明，公认的动脉粥样硬化危险因素促进了血管系统的炎性氧化环境，有利于内皮细胞病理变化的演变。现在有大量证据表明，内皮功能障碍是动脉粥样硬化的先兆，也是加速动脉粥样硬化的因素。因此，抗氧化剂营养素，包括维生素C、维生素E、β-胡萝卜素、硒和锌可能有助于减少内皮功能障碍，减少心血管事件的发生。然而，以前在临床试验中使用抗氧化剂补充剂的结果令人失望和有争议。在美国，饮食中抗氧化剂维生素的使用量继续增长。这项研究的目的是比较最广泛使用的补充剂和饮食抗氧化剂对内皮异常的不同标记物的影响。由于内皮功能障碍是动脉粥样硬化形成的关键潜在因素，内皮依赖性血管运动和循环内皮活动标志物(炎症标志物)的检测可能提供一种快速、可靠的方法来评估低成本的抗氧化剂治疗的临床结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A number of observational and experimental studies have shown that the recognized risk factors for atherosclerosis promote an inflammatory oxidative environment in the vasculature that is conducive to the evolution of pathologic changes in the endothelium. Considerable evidence now exists that endothelial dysfunction both precedes and accelerates atherosclerosis. Antioxidants nutrients, including vitamin C, vitamin E, beta-carotene, selenium, and zinc are therefore likely to contribute to a decrease of endothelial dysfunction and diminish the incidence of cardiovascular events. However, the previous use of antioxidant supplements in clinical trials has yielded disappointing and controversial results. The use of dietary antioxidant vitamins continues to grow in the US. The aim of this study is to contrast the effects of the most widely used supplemental and dietary antioxidants on different markers of endothelial abnormalities. As endothelial dysfunction is a key underlying factor in atherogenesis, tests of endothelium dependent vasomotion and on circulating markers of endothelial activity (inflammatory markers) may provide a rapid and reliable methodology to assess the clinical outcome of antioxidant procedures at low cost.