MRI

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。极低出生体重（<1500g； VLBW）早产儿占所有脑瘫（CP）患儿的25%。虽然这种疾病的脑损伤在新生儿早期（新生儿重症监护室）就已经存在，但CP的神经学表现直到1-2岁才明显。CP诊断的延迟导致干预的延迟，这可能会改善结果，并限制我们提高对CP病理生理学知识的能力。本研究的目的是检查VLBW早产疾病，在受孕后37周（出院前），用弥散张量脑MR成像测量表观扩散系数（ADC）和扩散各向异性。具体来说，我们期望在18个月矫正年龄时，在发生主要神经异常（包括CP）的高风险婴儿中，在脑的某些区域，如基底节区和脑白质中发现更高的扩散和更低的各向异性（表明损伤/延迟成熟）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Very low birth weight (<1500g; VLBW) preterm infants constitue 25% of all children with cerebral palsy (CP). Although the brain lesion underlying this disease is already present in early neonatal period (in the NICU) the neurological manifestation of CP is not apparent until 1-2 yrs of age. This delay in diagnosis of CP is responsible for delays in intervention which could improve outcome and limits our ability to advance our knowledge about the pathopysiology of CP. The aim of this study is to examine VLBW preterm disorders, at 37 weeks postconceptional age (before discharge), with apparent diffusion coefficient (ADC) and diffusion anisotropy measured by using diffusion tensor brain MR imaging. To be specific, we expect to find higher diffusion and lower anisotrophy (indication injury/delayed maturation) in MRI in certain regions of the brain such as basal ganglia and cerebral white matter in those infants at high risk for developing major neurological abnormalities, including CP, at 18-month corrected age.