RELATIONSHIP BETWEEN INSULIN RESISTANCE & EARLY DEVELOPMENT OF ATHEROGENESIS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的中心焦点一直集中在胰岛素介导的葡萄糖处置抵抗和代偿性高胰岛素血症在调节增加冠心病(CHD)风险的代谢变化方面的重要性。这些因素可能包括更明显的众所周知的冠心病风险因素，如血脂异常和高血压，以及其他导致X综合征的异常。除了关注这些风险因素，我们还将评估内皮依赖性血管扩张(内皮依赖性血管反应性，EDVR)的变化，以及构成动脉粥样硬化形成最早步骤的内皮-单核细胞相互作用的决定因素。因此，我们将尝试在胰岛素抵抗和与胰岛素作用缺陷相关的代谢异常之间建立联系。我们还将尝试建立与胰岛素抵抗和内皮依赖性血管扩张以及内皮-单核细胞相互作用的决定因素之间的联系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The central focus of this study has been on the importance of resistance to insulin-mediated glucose disposal and compensatory hyperinsulinemia in modulation of metabolic changes that increase risk of coronary heart disease (CHD). These can include more obvious well-know CHD risk factors, such as dyslipidemia and hypertension and others leading to the cluster of abnormalities known as Syndrome X. Besides focusing on these risk factors, we will also evaluate changes in endothelium-dependent vasodilation (endothelium-dependent vascular reactivity, EDVR) and determinants of endothelial-monocyte interaction that comprise the earliest steps in atherogenesis. Therefore, we will be attempting to establish a link between insulin resistance and the cluster of metabolic abnormalities associated with this defect in insulin action. We will also try and establish the link with insulin resistance and endothelium-dependent vasodilatation and determinants of endothelium-monocyte interaction.