EVAL OF PLANT STEROL ESTER & PLACEBO ON LOW-DENSITY LIPOPROTEIN CONCENTRATIONS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。降低胆固醇已被证明可以减少心脏病发作和与心脏病有关的死亡。在美国有许多药物可以降低胆固醇。一些药物被吸收到体内，并导致与其他药物的药物相互作用。然而，有些药物降低胆固醇而不被吸收到体内。最近，美汁源公司在美国推出了一种降低胆固醇的橙子汁。这项研究的目的是更好地了解降胆固醇药物Welchol（不会被人体吸收）与降胆固醇橙子汁（Minute Maid Heart Wise）联合使用对高胆固醇男性和女性的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lowering cholesterol has been shown to reduce heart attacks and deaths related to heart disease. There are many medications available in the U.S. to lower cholesterol. Some medications are absorbed into the body and cause drug interactions with other medications. However, some medications lower cholesterol without being absorbed into the body. Recently, orange juice that lowers cholesterol has been marketed in the U.S. by the Minute Maid Corporation. The goal of this study is to better understand the effects of the cholesterol-lowering drug Welchol¿, which is not absorbed into the body, in combination with cholesterol-lowering orange juice (Minute Maid Heart Wise¿) in men and women with high cholesterol.