Time-based high-content screening

迄今为止，显微镜和细胞成像还适用于小规模的实验样本。细胞分析的新方法需要满足细胞生物学、遗传学和实验治疗学的需求。核心是需要将图像转换为数字，这是一个重大的挑战，它将大大提高生物学家有效地询问和解释复杂数据的能力。为了实现大规模的成像实验，我们需要解决数据瓶颈的关键问题。高通量筛选仪器在过去五年中已经在商业部门可用，因此目标是将这些能力引入学术界。这样的设备不仅极大地增强了研究能力，而且为采用系统方法研究细胞生物学提供了新的机会。

Microscopy and cellular imaging has hitherto been amenable to small-scale experimental samples. New approaches to cell-based analysis are required to meet the demanding needs of cell-biology, genetics and experimental therapeutics. At the core is the need to convert images into numbers, this is a significant challenge which would greatly enhance the ability of the biologist to effectively interrogate and interpret complex data. To achieve large-scale imaging experiments we need to address critical issues of data bottlenecks. High-throughput screening instrumentation has been available in the commercial sector for the last five years, therefore the objective is to bring these capabilities to academia. Such equipment not only greatly augments research capacity but provides new opportunities taking a systems approach to cell-biology.