REVIVAL

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。对绝经后妇女的纵向和横断面研究表明，雌激素替代治疗后记忆任务的表现有所改善(Sherwin，2002；Duka T等人，2000；Smith Yr等人，2001；Maki等人，2001)。最近，使用富含异黄酮类植物雌激素的植物衍生产品，已知具有微弱的雌激素样作用，已被证明可以改善年轻男性和女性在短期和长期记忆测试中的表现(File等人，2001年)。本研究的目的是确定使用Revival是否能改善绝经后妇女的记忆功能。Revival是一种流行的膳食补充剂，含有自然产生的异黄酮。我们建议进行一项双盲、安慰剂对照的研究，研究异黄酮类膳食补充剂Revival对神经心理测试组合的影响，该测试包括评估100名绝经后女性的记忆功能(50名随机接受Revival治疗的女性，50名随机接受安慰剂治疗的女性)。我们假设，服用Revival将在绝经后妇女中导致更好的记忆表现，其方式类似于雌激素替代疗法，并与优降糖受试者的报告一致。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Longitudinal and cross-sectional studies of postmenopausal women indicate that performance on tasks of memory improves following estrogen replacement therapy (Sherwin, 2002 for a review; Duka T et al, 2000; Smith YR et al, 2001; Maki et al, 2001). Recently, the use of plant-derived products rich in isoflavone phytoestrogens, known to exert weak estrogenic action, have been shown to improve performance in young men and women on tests of short- and long-term memory (File et al., 2001). The purpose of the present study is to determine if the use of Revival, a popular dietary supplement containing naturally occurring isoflavones, leads to improved memory function in postmenopausal women. We propose to conduct a double-blind, placebo-controlled investigation of the effects of an isoflavone dietary supplement, Revival, taken for 12 weeks, on a neuropsychological test battery that includes assessment of memory function in 100 postmenopausal women (50 women randomized to receive Revival, 50 women randomized to receive placebo). We hypothesize that the ingestion of Revival will result in superior memory performance in postmenopausal women in a manner similar to that seen with estrogen replacement therapy, and consistent with reports in eugonadal subjects.