METABOLIC SYNDROME AND INFLAMMATION IN CHILDHOOD SLEEP APNEA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。代谢综合征（胰岛素抵抗、血脂异常、高血压和肥胖）与心血管发病率和死亡率的增加有关。在成人中发现代谢综合征与阻塞性睡眠呼吸暂停（OSA）之间存在关联。在成年OSA患者中，血清炎症标志物水平也有升高的记录。血清瘦素和生长激素是睡眠呼吸暂停中代谢紊乱的潜在介质，在阻塞性睡眠呼吸暂停成人间歇性低氧血症中升高。呼吸暂停严重程度和低氧血症似乎是葡萄糖耐量和胰岛素抵抗的独立预测指标。人们对儿童睡眠呼吸暂停对代谢的影响知之甚少。OSA与肥胖儿童空腹胰岛素、瘦素和CRP水平相关，但儿童睡眠呼吸暂停与独立于肥胖的代谢综合征的关系尚不清楚。儿童睡眠呼吸暂停与代谢综合征和炎症的关系需要调查，以确定成人睡眠呼吸暂停相关的心血管风险是否存在于儿童中。如果睡眠呼吸暂停与这些风险有关，如果代谢综合征通过睡眠呼吸暂停治疗得到改善，早期干预可能会改变成人睡眠呼吸暂停相关心血管后果的发病率。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The metabolic syndrome, (insulin resistance, dyslipidemia, hypertension, and obesity) is related to an increased risk for cardiovascular morbidity and mortality. An association between the metabolic syndrome and obstructive sleep apnea (OSA) has been found in adults. An increase in serum levels of inflammatory markers has also been previously documented in adult patients with OSA. Serum leptin and growth hormone, potential mediators of metabolic disturbances in sleep apnea, are increased by intermittent hypoxemia in adults with OSA. Apnea severity and hypoxemia appear to be independently predictive of glucose tolerance and insulin resistance. Little is known about the metabolic effects of sleep apnea in children. OSA correlates with serum levels of fasting insulin, leptin, and CRP levels in obese children, but the relationship of childhood sleep apnea and the metabolic syndrome independent of obesity is unknown. The association of childhood sleep apnea with the metabolic syndrome and inflammation requires investigation in order to determine if the cardiovascular risks associated with sleep apnea in adults are present in children. If sleep apnea is related to these risks, and if the metabolic syndrome is improved by sleep apnea treatment, early intervention may alter the morbidity of the cardiovascular consequences associated with sleep apnea in adults.