CEREBELLAR SYNDROMES: CLINICAL AND EXPERIMENTAL STUDY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。我们研究的最终目标是将来自广泛疾病实体的结构和功能数据整合到多维概率图谱中，我们将验证这一工具作为小脑功能的替代测量。这本质上是一个解剖学导向的数据库，包括临床、遗传、生理数据以及形态测量数据。该框架适用于多个功能领域的查询，我们的研究沿着三个相交的路径进行，以验证既广泛又深入的描述符。在这里，我们提出了一个综合的7年计划，将在精心选择的疾病队列中使用地图集的初始公式来回答小脑结构-功能关系的长期问题，然后开发一种自动图像分析方法，使地图集能够广泛使用。这是一项艰巨的任务，但考虑到JHMI广泛的设备资源，我们从神经病学、精神病学、放射学、生物医学工程、电气和计算机工程部门汇集的专业知识和努力，以及我们丰富的患者转诊基础，我们有独特的优势来完成这项任务。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The eventual goal of our research is to incorporate structural and functional data from a broad range of disease entities into a multidimensional probabilistic atlas, a tool that we will validate as a surrogate measure of cerebellar function. This is essentially an anatomically oriented database incorporating clinical, genetic, and physiologic data as well as morphometric data. This framework is suited to inquiry in multiple functional domains, and our study is directed along three intersecting paths in order to validate descriptors that are both broad and deep. Here we present an integrated 7-year plan that will use an initial formulation of the atlas in carefully selected disease cohorts to answer longstanding questions of structure-function relationship in the cerebellum, then develop a method for automated image analysis that will enable widespread use of the atlas. This is a tremendous undertaking, but given the extensive equipment resources of the JHMI, the expertise and effort we have assembled from the Departments of Neurology, Psychiatry, Radiology, Biomedical Engineering, and Electrical and Computer Engineering, and our rich patient referral base, we are uniquely positioned to accomplish this task.